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Acta Cirurgica Brasileira

On-line version ISSN 1678-2674

Abstract

CAVALLARI, Fransérgio Emílio et al. Expression of RANTES, eotaxin-2, ICAM-1, LFA-1 and CCR-3 in chronic rhinosinusitis patients with nasal polyposis. Acta Cir. Bras. [online]. 2012, vol.27, n.9, pp.645-649. ISSN 1678-2674.  https://doi.org/10.1590/S0102-86502012000900010.

PURPOSE: To compare gene expression of the chemokines RANTES and eotaxin-2, its receptor, CCR-3, adhesion molecule ICAM-1 and its receptor LFA-1 in eosinophilic polyps and in control normal nasal mucosa. METHODS: Gene expression was quantified by Real Time PCR in polyps (n=35) and in healthy nasal mucosa (n=15). RESULTS: Eosinophilic polyps showed a higher expression of eotaxin-2 and RANTES, but not of CCR-3, ICAM-1 or LFA-1 compared to control nasal mucosa. CONCLUSION: Eosinophilic polyps present greater expression of eotaxin-2 and RANTES, but not of CCR-3, ICAM-1 or LFA-1 compared to control nasal mucosa.

Keywords : Nasal Polyps; Chemokines; Intercellular Adhesion Molecule-1; Sinusitis.

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