Acta Cirurgica Brasileira
On-line version ISSN 1678-2674
KIELING, Carlos Oscar et al. The effects of anesthetic regimen in 90% hepatectomy in rats. Acta Cir. Bras. [online]. 2012, vol.27, n.10, pp.702-706. ISSN 1678-2674. http://dx.doi.org/10.1590/S0102-86502012001000006.
PURPOSE: To evaluate the influence of the anesthetic regimen on anesthetic recovery, survival, and blood glucose levels following a 90% partial hepatectomy in rats. METHODS: Thirty adult male Wistar rats were divided into two groups according to their anesthetic regimens: intraperitoneal ketamine and xylazine or inhaled isoflurane. In order to prevent hypoglycemia, glucose was administered intraperitoneally and glucose (20%) was added to the drinking water. RESULTS: Anesthetic recovery time was longer in the ketamine and xylazine group. The survival rate after 72 hours was lower (log rank=0.0001) in the ketamine and xylazine group (0.0%) than in the isoflurane group (26.7%). The blood glucose after six hours was lower (p=0.017) in the ketamine and xylazine group (63±31.7 mg/dL) than in the isoflurane group (98±21.2 mg/dL). The prolonged anesthesia recovery time associated with ketamine and xylazine decreased the survival rate and blood glucose levels after 90% hepatectomy. CONCLUSION: Isoflurane anesthesia reduced the recovery time and incidence of hypoglycemia and increased the survival rate in the early hours, providing a therapeutic window that is suitable for experimental studies.
Keywords : Liver Failure, Acute; Hepatectomy; Isoflurane; Ketamine; Xylazine; Ratos.