SciELO - Scientific Electronic Library Online

vol.27 issue10The effects of anesthetic regimen in 90% hepatectomy in ratsModified technique to increase nostril cross-sectional area after using rib and septal cartilage graft over alar nasal cartilages author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Acta Cirurgica Brasileira

On-line version ISSN 1678-2674


CITGEZ, Bulent et al. Effects of chitosan on healing and strength of colonic anastomosis in rats. Acta Cir. Bras. [online]. 2012, vol.27, n.10, pp.707-712. ISSN 1678-2674.

PURPOSE: To investigate whether chitosan application over colonic anastomosis line, provide reinforcement, and subsequently improve anastomotic healing. METHODS: Forty eight Wistar albino female rats were used and were randomly divided into four groups, 12 rats in each: The control groups (1 and 3) received no further treatment. The experimental groups (2 and 4) received chitosan application over the colonic anastomosis. After sacrifying rats at the end of the experiment (either on day three or on day seven, depending on the group), colonic bursting pressure, a hihydroxyproline level and histopathologic characteristics of the perianastomotic tissue were examined. RESULTS: At three days, chitosan and control groups had similar values for histopathologically. On day seven, chitosan group had significantly higher mean score of collagenization (p=0.007) and a significantly higher bursting pressure (p=0.038). CONCLUSION: Our study emphasizes the positive effect of chitosan in the process of collagenation in colonic anastomosis healing.

Keywords : Chitosan; Anastomosis, Surgical; Tensile Strength; Wound Healing; Rats.

        · abstract in Portuguese     · text in English     · English ( pdf epdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License