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Acta Cirurgica Brasileira

Print version ISSN 0102-8650

Abstract

FERNANDES, Tania Rita Moreno de Oliveira et al. Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide. Acta Cir. Bras. [online]. 2014, vol.29, n.1, pp.7-15. ISSN 0102-8650.  https://doi.org/10.1590/S0102-86502014000100002.

PURPOSE:

To study the possible potentiation of the carcinogenic effects of ultraviolet radiation associated with an organophosphate pesticide.

METHODS:

Forty Wistar rats were assigned into four groups (n=10 each) randomized according to the procedures: group A received only UVR-B radiation; group B, UVR-B for eight weeks followed by a seven week period of pesticide exposure; group C, UVR-B + pesticide concomitantly: group D, only pesticide application. At the end of the fifth, tenth and fifteenth weeks the animals were photographed. Skin biopsy and histopathological study with Hematoxylin-Eosin were done on the fifteenth week. Statistical analysis with Fisher's and Sign (unilateral) tests, 5% value for significance.

RESULTS:

Macroscopic lesions in the group A evolved from the erythema to erythema + desquamation. The groups B and C, with the association of two carcinogens, and group D presented evolution to keratosis, with higher incidence in group D. The histology showed a significant increase in the severity of injuries when the UVR-B and the pesticide were applied simultaneously, leading to cellular atypia.

CONCLUSIONS:

Concurrent association of UVR-B to organophosphate pesticide produced more severe lesions microscopically, although this has not been so apparent macroscopically. In daily practice the clinical evaluation should be complemented with laboratory evaluation.

Keywords : Epidermis; Solar Radiation; Skin Neoplasms; Organophosphates; Rats.

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