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Acta Cirúrgica Brasileira

Print version ISSN 0102-8650


YILMAZ, Dincer et al. Effect of platelet rich fibrin and beta tricalcium phosphate on bone healing. A histological study in pigs. Acta Cir. Bras. [online]. 2014, vol.29, n.1, pp.59-65. ISSN 0102-8650.


To investigate the effect of platelet rich fibrin (PRF) and beta tricalcium phosphate (β-TCP), alone or in combination, on bone regeneration in pig tibial defects.


Four standardized defects were prepared in both tibias of three adult male pigs. The first defect was left unfilled as a control; the others were grafted with either PRF, β-TCP or PRF mixed with β-TCP. All animals were sacrificed on the 12th postoperative week and the tibial bones were removed, histologic sections were prepared and the experimental sites were examined microscopically and stereologically.


Histologic and stereologic examination revealed more new bone formation in the defects filled with PRF mixed β-TCP than in the defects grafted with either β-TCP or PRF alone.


The platelet rich fibrin and beta tricalcium phosphate combination effectively induces new bone formation.

Keywords : Calcium Phosphates; Bone Regeneration; Tibia, Blood Platelets; Swine.

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