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Acta Cirurgica Brasileira

Print version ISSN 0102-8650

Abstract

YILMAZ, Dincer et al. Effect of platelet rich fibrin and beta tricalcium phosphate on bone healing. A histological study in pigs. Acta Cir. Bras. [online]. 2014, vol.29, n.1, pp.59-65. ISSN 0102-8650.  https://doi.org/10.1590/S0102-86502014000100009.

PURPOSE:

To investigate the effect of platelet rich fibrin (PRF) and beta tricalcium phosphate (β-TCP), alone or in combination, on bone regeneration in pig tibial defects.

METHODS:

Four standardized defects were prepared in both tibias of three adult male pigs. The first defect was left unfilled as a control; the others were grafted with either PRF, β-TCP or PRF mixed with β-TCP. All animals were sacrificed on the 12th postoperative week and the tibial bones were removed, histologic sections were prepared and the experimental sites were examined microscopically and stereologically.

RESULTS:

Histologic and stereologic examination revealed more new bone formation in the defects filled with PRF mixed β-TCP than in the defects grafted with either β-TCP or PRF alone.

CONCLUSION:

The platelet rich fibrin and beta tricalcium phosphate combination effectively induces new bone formation.

Keywords : Calcium Phosphates; Bone Regeneration; Tibia, Blood Platelets; Swine.

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