PURPOSE:
To evaluate the effect of diabetes mellitus and of sildenafil citrate on female urethral function.
METHODS:
Twenty nine female rats were divided into four groups: G1 - (n=9), normal rats; G2 - (n=6), normal rats treated with sildenafil citrate; G3 - (n=9) rats with alloxan-induced diabetes; G4 - (n=5) rats with alloxan-induced diabetes treated with sildenafil citrate. Under anesthesia, urodynamic evaluation was performed by cystometry and urethral pressure simultaneously.
RESULTS:
A significant increase in urethral pressure was observed during micturition.
CONCLUSION:
Sildenafil citrate can partially reduced urethral pressure in diabetic female rats.
Diabetes Mellitus; Urethra; Urinary Bladder; Rats