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Original Articles • Acta Cir. Bras. 29 (04) • Apr 2014 • https://doi.org/10.1590/S0102-86502014000400009   copy

Urethral dysfunction due to alloxan-induced diabetes. Urodynamic evaluation and action of sildenafil citrate1 1 Research performed at Laboratory of Surgical Technique and Experimental Surgery, Department of Surgery and Anatomy, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo (FMRP-USP). Ribeirao Preto-SP, Brazil. Part of PhD degree thesis, Postgraduate Program in Surgery, Department of Surgery and Anatomy, FMRP-USP. Tutor: Haylton Jorge Suaid.

Authorship SCIMAGO INSTITUTIONS RANKINGS

PURPOSE:

To evaluate the effect of diabetes mellitus and of sildenafil citrate on female urethral function.

METHODS:

Twenty nine female rats were divided into four groups: G1 - (n=9), normal rats; G2 - (n=6), normal rats treated with sildenafil citrate; G3 - (n=9) rats with alloxan-induced diabetes; G4 - (n=5) rats with alloxan-induced diabetes treated with sildenafil citrate. Under anesthesia, urodynamic evaluation was performed by cystometry and urethral pressure simultaneously.

RESULTS:

A significant increase in urethral pressure was observed during micturition.

CONCLUSION:

Sildenafil citrate can partially reduced urethral pressure in diabetic female rats.

Diabetes Mellitus; Urethra; Urinary Bladder; Rats

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