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Acta Cirurgica Brasileira

versão impressa ISSN 0102-8650versão On-line ISSN 1678-2674


FREITAS, Jose Octavio Gonçalves de et al. Does dexamethasone act in neuropeptides SP and CGRP in neurogenic inflammation of the skin? An experimental study. Acta Cir. Bras. [online]. 2015, vol.30, n.8, pp.523-528. ISSN 0102-8650.


To investigate the neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) after subcutaneous injection of dexamethasone prior to skin incision in rats.


Twenty seven Wistar-EPM-1 rats were randomly divided into three groups. The sham group (SG) of rats was injected with 0.9 % saline. The second group (Dexa) was injected with 1.0 mg/kg dexamethasone, and the third group (Dexa+) was injected with 10.0 mg/kg dexamethasone. In all groups, the three subcutaneous injections were performed 30 minutes prior to the surgical skin incision and tissue collection. SP and CGRP (15 kDa pro-CGRP and 5 kDa CGRP) were quantified by Western Blotting.


No statistically significant differences (p>0.05) were found in pro-CGRP, CGRP and SP values in all three groups.


The anti-inflammatory effect of dexamethasone did not occur when the substance P and calcitonin gene-related peptide levels were altered during the neurogenic inflammation process of skin wound healing in rats.

Palavras-chave : Calcitonin Gene-Related Peptide; Substance P; Neuropeptides; Dexamethasone; Neurogenic Inflammation; Skin; Rats.

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