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Original Articles • Acta Cir. Bras. 31 (3) • Mar 2016 • https://doi.org/10.1590/S0102-865020160030000007   copy

Borage oil attenuates progression of cardiac remodeling in rats after myocardial infarction1 1 Research performed at Experimental Surgery Laboratory, Faculty of Medicine, Universidade da Cidade de São Paulo (UNICID), Brazil. Part of Master degree thesis, Postgraduate Program in Health Science. Tutor: Profa. Marcia Kiyomi Koike

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

PURPOSE:

To investigate the effects of Borage oil on cardiac remodeling after myocardial infarction (MI).

METHODS:

Male Wistar rats underwent ligation of the left coronary artery and divided into three groups: MI (control), BO-18 (18 mg/kg of borage oil) and BO-180 (180 mg/kg of borage oil). After seven days, heart was arrested in diastole and processed for histological evaluation of: MI size, LV dilation, myocyte hypertrophy, inflammatory infiltration and fibrosis in MI region and in remote region. The relative weight of the lung was used as a marker of heart failure. The MI size was comparable among groups.

RESULTS:

Compared to control, BO treated groups showed lower weight of heart and lungs, reduced LV dilation and myocyte hypertrophy. Hemodynamic measurements were comparable. The treatment attenuated the inflammatory infiltration and fibrosis in remote myocardium.

CONCLUSION:

Borage oil attenuates progression of cardiac remodeling after myocardial infarction and congestive heart failure.

Key words:
Myocardial Infarction. Ventricular Remodeling. Fatty Acids; Omega-6. Rats

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