Acessibilidade / Reportar erro

Noradrenaline and dobutamine effects on the volume expansion with normal saline in rabbits subjected to hemorrhage1 1 Research performed at Experimental Laboratory of Anesthesiology, Botucatu Medical School, Universidade Estadual Paulista (UNESP), Brazil. PhD degree thesis, Postgraduate Program in Anesthesiology, UNESP. Tutor: Luiz Antonio Vane

ABSTRACT

PURPOSE:

To evaluate the effects of dobutamine (DB), noradrenaline (NA), and their combination (NADB), on volume retention in rabbits submitted to hemorrhage.

METHODS:

Thirty six rabbits were randomly divided into 6 groups: SHAM, Control, Saline, DB, NA, DB+NA. All the animals, except for SHAM, were subjected to hemorrhage of 25% of the calculated blood volume. Control animals were replaced with their own blood. The other groups received NSS 3 times the volume withdrawn. The intravascular retention, hematocrit, diuresis, central venous pressure, mean arterial pressure, NGAL, dry-to-wet lung weight ratio (DTWR) and the lung and kidney histology were analyzed.

RESULTS:

Replacement with NSS and NA, DB or NA+DB did not produce differences in the intravascular retention. After hemorrhage, the animals presented a significant decrease in the MAP and CVP, which were maintained until volume replacement. Regarding NGAL, dry-to-wet-lung-weight ratio, lung and kidney histology, there were no statistical differences between the groups.

CONCLUSION:

The use of noradrenaline, dobutamine or their combination did not increase the intravascular retention of volume after normal saline infusion.

Key words:
Plasma Volume; Hemorrhage; Catecholamines; Rabbits

Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia https://actacirbras.com.br/ - São Paulo - SP - Brazil
E-mail: actacirbras@gmail.com