Animal models of obesity in rodents. An integrative review1

Research was conducted in the CAPES Portal database using the following keywords "obesity animal models, diet and rodents", published between the years 2010 to 2016. We found 108 articles, of which 19 were selected and analyzed in full for this study.

RESULTS:

Larger part of publications occurred in the last 6 years, the rats (n = 10) were used in the same proportion mice (n = 10). The choice of male animals (n = 18) and age greater than 21 days (n = 17) showed a major highlight. The greater than 5 week follow-up period (n = 18) was the most applied. A High Fat Diet was the most used in studies (n = 18) .

CONCLUSIONS:

Male rodents continue to be considered the species most used in experimental studies to induce obesity, also was found variations of age to the beginning of the experiment. For the most part are follow-up time studies along with the use of High Fat Diet.

Key words:
Obesity; Animal Experimentation; Diet; Rodentia

Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia https://actacirbras.com.br/ - São Paulo - SP - Brazil
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[1] Correspondence: Melina Ribeiro Fernandes Rua Cora Coralina, 153/02 79040-510 Campo Grande - MS Brasil Tel.: (55 67)99226-7227fernandesrmelina@gmail.com

AUTORS	TYPE OF ANIMAL	AGE	SEX	FOLLOW-UP TIME	TYPE OF DIET
Privi-tera¹⁰	Rats SD	21 days	Male	13 weeks	High Fat 60%
Watanabe¹¹	Mice C57BL	6 a 7 weeks	Male	96 days	High Fat 60%
Calli-garis¹²	Mice C57BL	5 weeks	Male	16 months	High Fat 60%
Krüger¹³	Mice C57BL	10-12 weeks	Male	10 weeks	High Fat
Walewski¹⁴	Rats wistar Mice C57BL	18 weeks	Female	20 weeks	High Fat 60%
Borengasse¹⁵	Rats SD	60 days	Male and Female	12 weeks	High Carb72%, High Fat 40-45%
Lalanza¹⁶	Rats SD	21 days	Male and Female	8 weeks	Cafeteria
Shao¹⁷	Mice C57BL	8 weeks	Male	12 weeks	High Fat 40%
Tillman¹⁸	Mice C57BL	ND	Male	14 weeks	High Carb, High Fat 45%; 67%
Guan¹	Rats SD	ND	Male	90 days	High Fat, High Carb
Mc pherson²	Mice C57BL	5 weeks	Male	9 weeks	High Fat 21%
Qian²¹	Rats SD	ND	Male	12 weeks	High Fat
Quiñones²²	Rats SD	6 weeks	Male	10 weeks	High Fat 60%, Low Fat 10%
Roberts-tole²³	Mice C57BL	6 weeks	Male	16- 22 weeks	High Fat 60%, Hight.Carb 70%
Zhuhua²⁴	Mice ICR	8 weeks	Male	12 weeks	High Fat, High Carb

VARIABLE	TOTAL
Year of Publication
2010-2011	05
2012-2013	03
2014-2015	11
Animal Species
Mice	10
Rats	10
Age of animals
21 days	02
4 a 8 weeks	11
≥ 8 weeks	02
ND	04
Sex of Animals
Male	16
Female	01
Ambos	02
Follow-up time
6 a 10 weeks	05
11 a 16 weeks >16 weeks	09 05
Type of diet
High Fat	18
High Carb	06
Cafeteria	01

Brasil

Brasil

Animal models of obesity in rodents. An integrative review1 1 Research performed at Postgraduate Program in Health and Development, Midwest Region, Universidade Federal do Mato Grosso do Sul (UFMS), Campo Grande-MS, Brazil.

ABSTRACT

PURPOSE:

METHODS:

RESULTS:

CONCLUSIONS:

Animal models of obesity in rodents. An integrative review^¹ 1 Research performed at Postgraduate Program in Health and Development, Midwest Region, Universidade Federal do Mato Grosso do Sul (UFMS), Campo Grande-MS, Brazil.