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Acta Cirurgica Brasileira

Print version ISSN 0102-8650On-line version ISSN 1678-2674

Abstract

GUIMARAES, Ana Paula Franttini Garcia Moreno et al. Nandrolone decanoate appears to increase bone callus formation in young adult rats after a complete femoral fracture. Acta Cir. Bras. [online]. 2017, vol.32, n.11, pp.924-934. ISSN 0102-8650.  https://doi.org/10.1590/s0102-865020170110000004.

Purpose:

To evaluate the influence of nandrolone decanoate on fracture healing and bone quality in normal rats.

Methods:

Male rats were assigned to four groups (n=28/group): Control group consisting of animals without any intervention, Nandrolone decanoate (DN) group consisting of animals that received intramuscular injection of nandrolone decanoate, Fracture group consisting of animals with a fracture at the mid-diaphysis of the femur, and Fracture and nandrolone decanoate group consisting of animals with a femur fracture and treatment with nandrolone decanoate. Fractures were created at the mid-diaphysis of the right femur by a blunt trauma and internally fixed using an intramedullary steel wire. The DN was injected intramuscularly twice per week (10 mg/kg of body mass). The femurs were measured and evaluated by densitometry and mechanical resistance after animal euthanasia. The newly formed bone and collagen type I levels were quantified in the callus.

Results:

The treated animals had longer femurs after 28 days. The quality of the intact bone was not significantly different between groups. The bone callus did show a larger mass in the treated rats.

Conclusion:

The administration of nandrolone decanoate did not affect the quality of the intact bone, but might have enhanced the bone callus formation.

Keywords : Anabolic Agents; Femoral Fractures; Bony Callus; Rats..

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