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Acta Cirurgica Brasileira

Print version ISSN 0102-8650On-line version ISSN 1678-2674

Abstract

RIBEIRO JUNIOR, Rubens Fernando Gonçalves et al. Perconditioning associated to hypertonic saline solution on liver function improvement after ischemia/reperfusion injury. Acta Cir. Bras. [online]. 2017, vol.32, n.11, pp.949-955. ISSN 0102-8650.  https://doi.org/10.1590/s0102-865020170110000006.

Purpose:

To evaluate the effects of hypertonic saline solution associated to remote ischemic perconditioning in liver ischemia/reperfusion injury in rats.

Methods:

25 male rats (Wistar) were distributed into five groups: Sham group (S); Ischemia/Reperfusion group (I/R) with 30 minutes of liver ischemia; Remote ischemic perconditioning group (Per) with three cycles of 10 minutes of I/R performed during liver ischemia; Hypertonic saline solution group (HSS) treated with hypertonic saline solution (4ml/kg); Remote ischemic perconditioning + Hypertonic saline solution group (Per+HSS) with both treatments.

Results:

Per+HSS group showed a lower degree of liver dysfunction in relation to I/R group, whereas the technique of remote ischemic perconditioning isolated or associated with saline solution significantly improved liver function and reduced histological damage.

Conclusion:

Remote ischemic perconditioning associated or not to saline solution promoted reduction of acute liver injury induced by ischemia/reperfusion.

Keywords : Ischemia; Reperfusion; Saline Solution, Hypertonic; Liver; Rats..

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