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Acta Cirurgica Brasileira

Print version ISSN 0102-8650On-line version ISSN 1678-2674

Abstract

EKEN, Hüseyin et al. Effect of taxifolin on oxidative gastric injury induced by celiac artery ligation in rats. Acta Cir. Bras. [online]. 2019, vol.34, n.4, e201900404.  Epub May 06, 2019. ISSN 0102-8650.  https://doi.org/10.1590/s0102-865020190040000004.

Purpose:

To examine the effect of taxifolin on I/R induced gastric injury in rats using biochemical and histopatholohical methods.

Methods:

Eighteen albino Wistar male rats equally grouped as; gastric I/R (I/R), 50 mg/kg taxifolin + gastric I/R (TAX+ I/R) and sham operation applied (SHAM). Ischemia induced for 1 hour, and reperfusion induced for 3 hours.

Results:

Oxidant parameters like, Malondialdehyde (MDA) and Hydroxyguanine (8-OHdG) were higher, whereas total glutathione (tGSH) was lower in the I/R group according to SHAM group, histopathological findings such as marked destruction, edema, and proliferated dilated congested blood vessels were observed severely in the I/R group, whereas there was not any pathological finding except mild dilated congested blood vessels in the TAX+ I/R group.

Conclusion:

The taxifolin can be clinically beneficial in the treatment of gastric injury due to I/R procedure.

Keywords : Taxifolin; Celiac Artery; Ischemia; Reperfusion; Rats.

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