SciELO - Scientific Electronic Library Online

vol.26 issue2More than one decade of the Baby-Friendly Health Care Initiative in Brazil: thinking about the futureNeurofibromatosis type 1 in childhood: review of clinical aspects author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Revista Paulista de Pediatria

Print version ISSN 0103-0582On-line version ISSN 1984-0462


SILVA, Dáfne Cardoso B. da et al. Use of epidermic and granulocyte-colony stimulating growth factors in the prevention and treatment of necrotizing enterocolitis of the newborn. Rev. paul. pediatr. [online]. 2008, vol.26, n.2, pp.170-175. ISSN 1984-0462.

OBJECTIVE: To review the literature regarding the use of hematopoietic and epidermic growth factors for prevention or treatment of neonatal necrotizing enterocolitis (NEC). DATA SOURCES: Literature review of Medline, Lilacs, SciELO and Pubmed databases, using the key-words "newborn", "enterocolitis" and "growth factors", from 2003 to 2007. Fourty-nine papers were retrieved, but only 17 related to the subject. Other studies that described some clinical aspects of enterocolitis were also included, regardless of the year of publication. DATA SYNTHESIS: Necrotizing and enterocolitis has been an important cause of morbidity and mortality in the neonatal period. As the knowledge about the pathophysiology of this disease improves, new therapies, such as the administration of epidermal growth factor and granulocyte colony-stimulating factor, are being discussed. CONCLUSIONS: The use of growth factors for treatment and prevention of NEC seems promising. However, further clinics assays are needed to evaluate the effectiveness and the safety of these growth factors. At this moment, the best clinical practice is the prevention of the disease.

Keywords : infant, newborn; diet therapy; growth factors; enterocolitis, necrotizing.

        · abstract in Portuguese     · text in Portuguese     · Portuguese ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License