Pappa et al[30] 2006 USA |
Report the prevalence of vitamin D deficiency in IBD |
n. 130/ c. 0/ 8 months-2 years |
The prevalence of vitamin D deficiency was 34.6 %. |
Mean serum [25 OHD] was similar in patients with CD and URC |
Vitamin D deficiency is highly prevalent among pediatric patients with IBD. |
Kugathasan et al[25] 2007 USA |
Compare the BMI of all children with a recent diagnosis of IBD in two independent groups |
n. 783/ c. 2,748/ <16 years |
Most children with IBD had normal BMI (5% 84%). |
BMI <5% was observed in 24% of children with CD and 9% in URC. 10% of the children with CD and 30% of those with URC had BMI consistent with overweight or risk of overweight. |
Children with IBD are affected by current population trends in relation to overweight. A subgroup of children with newly diagnosed IBD has a BMI classified as overweight or at risk of overweight. |
Thayu et al[28] 2007 USA |
To evaluate lean mass and fat mass in children and adolescents with CD at diagnosis. |
n. 78/c. 669/ 5-21 years |
CD was associated with height, BMI, lean and fat mass that was low for age. |
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CD was associated with deficits in lean mass and fat mass. |
Sylvester et al[33] 2009 USA |
Observe the effects of CD on body composition in a cohort of children over a period of two years |
n. 42/ c. 81/ 6-17 years |
BMI z was reduced at diagnosis in children with CD compared with controls. During the study period of 2 years, BMI z scores will normalize in patients with CD. |
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The correction of BMI is associated with clinical improvement in children with CD two years after diagnosis |
Heyman et al[32] 2009 USA |
Compare folate concentrations between children with newly diagnosed IBD and healthy controls |
n. 37/ c. 41/ 5 to 17 years |
Serum folate concentrations were 11.1% lower in controls than in patients with IBD (p=0.031). |
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Higher folate concentrations were observed in children with newly diagnosed untreated IBD than in the controls. |
Lee et al[26] 2010 USA |
Compare final adult height of patients and the target height based on the heights of parents. |
n. 295/c. 569/ 1-18 years |
22% had impaired growth (zH /A<-1.64, equivalent to percentile <5). Only 11.3% with impaired growth up to adulthood. |
Most patients with growth problems had CD (88% CD vs. 12% URC) |
Most patients with IBD do not persist with impaired growth in adulthood. |
Long et al[24]2011 USA |
Determine the prevalence of obesity in a multicentric cohort of children with IBD |
n. 1,598/ c. 0/ 2-18 years |
The prevalence of overweight and obesity in children and adolescents with IBD was 23.6%. |
Higher rates of overweight and obesity were found in URC than in CD (30.1% and 20.0%, respectively) |
Approximately 1/5 of children with CD and 1/3 with URC are overweight or obese. Obesity rate in URC is comparable to that of the general population. |
Pappa et al[29] 2011 USA |
To evaluate the prevalence of hypovitaminosis D in children and adolescents with IBD. |
n. 448/ c. /8-22 years |
Serum [25-OHD] ≤20ng/mL (insufficiency) identified in 14.3% of patients and serum [25-OHD] ≤15ng/mL (deficiency) in 5.8%. |
Both patients with URC and CD are at risk of hypovitaminosis D. |
Hypovitaminosis D is prevalent among children and young individuals, including patients with IBD. |
Levin et al[31] 2011 Australia |
Document the 25-OHD status in a population of Australian children with IBD. |
n. 78/ c. 0/ mean age of 12.6 (±3.5) years |
19% of the children had vitamin D deficiency and 38% had vitamin D insufficiency. |
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A high proportion of Australian children with IBD were vitamin-D deficient. |
Wiskin et al[23] 2011 UK |
Describe the height, weight and body composition in a cohort of children with IBD. |
n. 55/ c. 0/ 6.5-17.7 years |
Malnutrition rate, according to the WHO criteria, was 2.2%. Growth deficit of 18.2% among the studied children. |
Nutritional deficits were more common in Crohn's disease |
Most children showed satisfactory height and weight, although some children were underweight for height and others were overweight. |
Aurangzeb et al[22] 2011 Pakistan |
Define the nutritional status of children with newly diagnosed IBD |
n. 28 c. 56 6 months to 16 years |
Children with IBD have BMI z score and weight percentile for age lower than controls (p=0.05 and p=0.01, respectively) |
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Detailed nutritional assessment should be an integral part of the conduct for all children with IBD. |
Hood et al[27] 2011 USA |
Compare heights at expected age of cessation of growth (16 for girls and 18 for boys) with those obtained after two years. |
n. 475/ c. 0/ 16-20 years |
Compared to the general population (163.8 cm at age 16 in girls and 176.8 cm at age 18 in boys), girls and boys with IBD were 2.7 cm and 2.6 cm shorter, respectively. |
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Most patients with IBD reach adult height within normal values for the population. |