Batra et al.1212. Batra V, Sethi GR, Sachdev HP. Comparative efficacy of jet nebulizer and metered dose inhaler with spacer device in the treatment of acute asthma. Indian Pediatr. 1997;34:497-503.
|
1997 |
India |
1 a 12 |
60 |
0.15 mg/kg salbutamol (max. 5.00 mg) |
200 µg salbutamol |
MDI-spacer is as effective as aerosol nebulizer (salbutamol) for acute asthma exacerbation in children |
Chong-Neto et al.1313. Chong Neto HJ, Chong-Silva DC, Marani DM, Kuroda F, Olandosky M, Noronha L. Different inhaler devices in acute asthma attacks: a randomized, double-blind, placebo-controlled study. J Pediatr (Rio J). 2005;81:298-304.
|
2005 |
Brazil |
6 a 18 |
580 |
5 mg/mL albuterol |
400 µg salbutamol |
Nebulizer has higher cost and consumes more drugs than MDI-spacer |
Delgado et al.1414. Delgado A, Chou KJ, Silver EJ, Crain EF. Nebulizers vs metered-dose inhalers with spacers for bronchodilator therapy to treat wheezing in children aged 2 to 24 months in a pediatric emergency department. Arch Pediatr Adolesc Med. 2003;157:76-80.
|
2003 |
USA |
0 a 2 |
40 |
0.15 mg/kg salbutamol (max. 5.00 mg) |
300 µg salbutamol |
Metered-dose inhalers with spacers may be as effective as nebulizers for emergency treatment of wheezing in children aged ≤2 years |
Fernandez et al.1515. Benito-Fernandez J, Gonzalez-Balenciaga M, Capape-Zache S, Vazquez-Ronco MA, Mintegi-Raso S. Salbutamol via metered-dose inhaler with spacer versus nebulization for acute treatment of pediatric asthma in the emergency department. Pediatr Emerg Care. 2004;20:656-9.
|
2004 |
Spain |
0 a 14 |
251 |
2.5 mg/mL salbutamol |
200 µg salbutamol |
MDI-spacer is as effective as aerosol nebulizers (salbutamol) for acute asthma exacerbation in children |
Jamalvi et al.1616. Jamalvi SW, Raza SJ, Naz F, Shamim S, Jamalvi S. Management of Acute Asthma in children using metered dose in inhaler and small volume nebulizer. J Pakistan Med Assoc. 2006;56:595-9.
|
2006 |
Pakistan |
0 a 15 |
150 |
0.3 mg/kg salbutamol (max. 5.0 mg) |
200 µg salbutamol |
MDI-spacer is an effective alternative, as well as nebulizers, to treat children with exacerbation of acute asthma at emergency rooms |
Kerem et al.1717. Kerem E, Levison H, Schuh S, O'Brodovich H, Reisman J, Bentur L, et al. Efficacy of albuterol administered by nebulizer versus spacer device in children with acute asthma. J Pediatr. 1993;123:313-7.
|
1993 |
Canada |
6 a 14 |
33 |
5 mg/mL albuterol |
400 µg salbutamol |
MDI-spacer and nebulizers are equally effective to administer β 2 agonists in children with acute asthma |
Leversha et al.1818. Leversha AM, Campanella SG, Aickin RP, Asher MI. Costs and effectiveness of spacer versus nebulizer in young children with moderate and severe acute asthma. J Pediatr. 2000;136:497-502.
|
2000 |
New Zealand |
1 a 4 |
60 |
2.5 mg/mL salbutamol |
600 µg salbutamol |
MDI-spacer is a low-cost alternative to administer salbutamol in children with moderate and severe acute asthma |
Sannier et al.1919. Sannier N, Timsit S, Cojocaru B, Leis A, Wille C, Garel D, et al. Traitement aux urgences des crises d'asthme par nébulisations vs chambres d'inhalation. Arch. Pédiat. 2006;13:238-44.
|
2006 |
France |
4 a 15 |
79 |
0.15 mg/kg salbutamol (max. 3.00 mg) |
300 µg salbutamol |
MDI-spacer is a low-cost alternative for the administration of salbutamol to children with acute asthma at emergency rooms |
Vilarinho et al.2020. Vilarinho L, Mendes CM, Souza L. Metered-dose inhalers with home-made spacers versus nebulizers to treat moderate wheezing attacks in children. J Pediatr (Rio J). 2003;79:403-12.
|
2003 |
Brazil |
0 a 11 |
54 |
250 µg/drop salbutamol |
100 µg salbutamol per 3 kg of weight |
MDI-spacer can be used to administer salbutamol to children in wheezing crisis, with some advantages over the nebulizer |