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Banaszkiewicz et al., 20051818. Banaszkiewicz A, Szajewska H. Ineffectiveness of Lactobacillus GG as an adjunct to lactulose for the treatment of constipation in children: a double-blind, placebo-controlled randomized trial. J Pediatr. 2005;146:364-9. https://doi.org/10.1016/j.jpeds.2004.10.022 https://doi.org/https://doi.org/10.1016/...
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Poland
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L. rhamnosus GG (ATCC 531032) |
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Treatment successa was similar (p> 0.05) at the 12th week (experimental group=72% and control group=68%) and at the 24th week (experimental group =64% and control group=65%).
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There was no difference between the groups regarding weekly number of bowel movements, the force of the bowel movement, fecal escape and the number of required doses of laxatives.
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Bu et al., 20072121. Bu LN, Chang MH, Ni YH, Chen HL, Cheng CC. Lactobacillus casei rhamnosus Lcr35 in children with chronic constipation. Pediatr Int. 2007;49:485-90. https://doi.org/10.1111/j.1442-200X.2007.02397.x https://doi.org/https://doi.org/10.1111/...
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Taiwan
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L. casei rhamnosus Lcr35 |
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Greater (p=0.01) treatment successa in the magnesium oxide (72.2%) and probiotic (77.8%) groups compared to the placebo (11.1%).
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The magnesium oxide and probiotic groups presented a higher (p = 0.03) frequency of bowel movement, a lower (p = 0.01) frequency of hardened stools and a lower (p = 0.04) frequency of glycerin enema use in comparison to the placebo.
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Episodes of abdominal pain were less frequent (p = 0.03) in the probiotic group compared to the magnesium oxide and placebo groups.
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There was an increase in the percentage of lactobacilli in anaerobic microbiota after probiotic treatment (p = 0.03) and when compared to the magnesium oxide and placebo groups (p = 0.02), there was no correlation with bowel movement frequency.
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There was no difference between the groups regarding the frequency of lactulose use, bowel movement episodes and appetite alteration.
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Coccorullo et al., 20101616. Coccorullo P, Strisciuglio C, Martinelli M, Miele E, Greco L, Staiano A. Lactobacillus reuteri (DSM 17938) in infants with functional chronic constipation: a double-blind, randomized, placebo-controlled study. J Pediatr. 2010;157:598-602. https://doi.org/10.1016/j.jpeds.2010.04.066 https://doi.org/https://doi.org/10.1016/...
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Italy
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Lactobacillusreuteri DSM 17938 |
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No definition of therapeutic success.
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Higher frequency of probiotic bowel movements in the second (p = 0.042), fourth (p = 0.008) and eighth (p = 0.027) weeks of treatment versus the control.
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There was no difference between groups with regard to stool consistency.
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There was an increase (p = 0.02) of inconsolable crying episodes in the probiotic group. In the control group, an increase in inconsolable crying was also observed, however, it did not reach statistical significance (p = 0.08).
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Tabbers et al., 20112020. Tabbers MM , Chmielewska A, Roseboom MG, Crastes N, Perrin C, Reitsma JB, et al. Fermented milk containing Bifidobacterium lactis DN-173 010 in childhood constipation: a randomized, double-blind, controlled trial. Pediatrics. 2011;127:e1392-9. https://doi.org/10.1542/peds.2010-2590 https://doi.org/https://doi.org/10.1542/...
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Holland and Poland
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Bifidobacterium lactis DN-173 010 (n=74) |
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Treatment successb was higher in the probiotic group (38%) compared to the placebo group (24%), but there was no significant difference (p=0.06).
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In the probiotic group, a reduction (p = 0.02) in flatulence frequency was observed.
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There was no difference between the probiotic and control groups regarding bowel movement frequency, stool consistency, fecal incontinence, pain during bowel movements, abdominal pain and bisacodil use.
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Higher bisacodil intake was observed in the control group (p=0.0069).
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Guerra et al.,
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20112222. Guerra PV, Lima LN, Souza TC, Mazochi V, Penna FJ, Silva AM, et al. Pediatric functional constipation treatment with Bifidobacterium-containing yogurt: a crossover, double-blind, controlled trial. World J Gastroenterol. 2011;17:3916-21. https://doi.org/10.3748/wjg.v17.i34.3916 https://doi.org/https://doi.org/10.3748/...
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Brazil
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Bifidobacterium longum (n = 29) |
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They do not present total data obtained in the two intervention periods with probiotic or control. They mention that in the probiotic group, considering all the results, there was a significant difference in the frequency of bowel movements, pain in bowel movements and abdominal pain.
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Sadeghzadeh et al., 20142323. Sadeghzadeh M, Rabieefar A, Khoshnevisasl P, Mousavinasab N, Eftekhari K. The effect of probiotics on childhood constipation: a randomized controlled double blind clinical trial. Int J Pediatr . 2014;2014:937212. https://doi.org/10.1155/2014/937212 https://doi.org/https://doi.org/10.1155/...
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Iran
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Protexin®
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No definition of therapeutic success.
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At the end of the fourth week it was found that the probiotic group had a higher (p = 0.042) bowel movement frequency and an improvement (p = 0.049) in stool consistency when compared to the placebo group.
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In the first week of intervention, a lower (p=0.030) frequency of fecal incontinence, a lower frequency (p=0.017) of abdominal pain and a greater weight gain (p=0.002) was found. These variables were similar in the fourth week of the study.
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Russo et al., 20171717. Russo M, Giugliano FP, Quitadamo P, Mancusi V, Miele E , Staiano A . Efficacy of a mixture of probiotic agents as complementary therapy for chronic functional constipation in childhood. Ital J Pediatr. 2017;43:24. https://doi.org/10.1186/s13052-017-0334-3 https://doi.org/https://doi.org/10.1186/...
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Italy
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Brief bifidobacterium M-16 V® , Infant Bifidobacterium M-63® and Bifidobacterium longum BB536®.
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Bifidobacterium longum BB536®
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In the second week of the study, treatment successc was higher with PEG (72%) compared to the PEG + probiotic mixture group (59%) (p=0.02).
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After one month (the fourth week), there was no difference in treatment success between the PEG group (88%) and the PEG + probiotic mixture group (81.8%).
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There was no difference between groups regarding bowel movement frequency, stool consistency, abdominal pain, fecal incontinence and rectal bleeding after two months (eighth week) of study.
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One month after the end of the study (12nd week), a clinical remission rate was observed in the PEG + probiotic mixture group in 64% of patients and 52% in the PEG-only group (p=0.28).
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Wojtyniak et al., 20171919. Wojtyniak K, Horvath A, Dziechciarz P, Szajewska H . Lactobacillus casei rhamnosus Lcr35 in the management of functional constipation in children: a Randomized Trial. J Pediatr. 2017;184:101-5. https://doi.org/10.1016/j.jpeds.2017.01.068 https://doi.org/https://doi.org/10.1016/...
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Poland
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There was no difference in treatment successa between the groups.
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In the probiotic group, there was a lower (p = 0.005) bowel movement frequency in allof the studied weeks compared to the placebo group.
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Comparing from the baseline to the fourth week of study, there was an increase (p<0.001) in bowel movement frequency and an improvement (p<0.001) in stool consistency in both groups.
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