Frequência |
WNT |
16,3% |
11,0%1414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
|
SHH |
34,7% |
28,0%1414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
|
Grupo não WNT/não SHH |
49,0% |
61,0%1414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
|
Gênero (M:F) |
WNT |
0,6:1 |
1:11414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
,2525. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123:465-72. https://doi.org/10.1007/s00401-011-0922-z https://doi.org/https://doi.org/10.1007/...
|
SHH |
3,2:1 |
1:11414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
,2525. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123:465-72. https://doi.org/10.1007/s00401-011-0922-z https://doi.org/https://doi.org/10.1007/...
|
Grupo não WNT/não SHH |
2,4:1 |
2:11414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
,2525. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123:465-72. https://doi.org/10.1007/s00401-011-0922-z https://doi.org/https://doi.org/10.1007/...
|
Faixa etária |
WNT |
todos 3-16 |
maioria 3-161414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
,2525. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123:465-72. https://doi.org/10.1007/s00401-011-0922-z https://doi.org/https://doi.org/10.1007/...
|
SHH |
maioria 3-16 |
maioria <3 ou >161414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
,2525. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123:465-72. https://doi.org/10.1007/s00401-011-0922-z https://doi.org/https://doi.org/10.1007/...
|
Grupo não WNT/não SHH |
maioria 3-16 |
<3 e 3-161414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
,2525. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123:465-72. https://doi.org/10.1007/s00401-011-0922-z https://doi.org/https://doi.org/10.1007/...
|
Histologia |
WNT |
maioria clássico |
maioria clássico1414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
,2525. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123:465-72. https://doi.org/10.1007/s00401-011-0922-z https://doi.org/https://doi.org/10.1007/...
|
SHH |
maioria desmoplásico |
clássico, desmopl., A/GC1414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
,2525. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123:465-72. https://doi.org/10.1007/s00401-011-0922-z https://doi.org/https://doi.org/10.1007/...
|
Grupo não WNT/não SHH |
maioria clássico |
clássico, A/GC1414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
,2525. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123:465-72. https://doi.org/10.1007/s00401-011-0922-z https://doi.org/https://doi.org/10.1007/...
|
Metástase |
WNT |
25% |
Raro (9%)1414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
,2525. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123:465-72. https://doi.org/10.1007/s00401-011-0922-z https://doi.org/https://doi.org/10.1007/...
|
SHH |
23% |
Incomum (17-22%)1414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
,2525. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123:465-72. https://doi.org/10.1007/s00401-011-0922-z https://doi.org/https://doi.org/10.1007/...
|
Grupo não WNT/não SHH |
70% |
muito frequente (30-47%)1414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
,2525. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123:465-72. https://doi.org/10.1007/s00401-011-0922-z https://doi.org/https://doi.org/10.1007/...
|
Prognóstico* |
WNT |
75% |
Melhor (>90%)1414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
,2525. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123:465-72. https://doi.org/10.1007/s00401-011-0922-z https://doi.org/https://doi.org/10.1007/...
|
SHH |
58,8% |
Intermediário (68-75%)1414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
,2525. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123:465-72. https://doi.org/10.1007/s00401-011-0922-z https://doi.org/https://doi.org/10.1007/...
|
Grupo não WNT/não SHH |
66,7% |
Pior (45-58%)1414. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-84. https://doi.org/10.1007/s00401-012-0958-8 https://doi.org/https://doi.org/10.1007/...
,2525. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123:465-72. https://doi.org/10.1007/s00401-011-0922-z https://doi.org/https://doi.org/10.1007/...
|