Sung et al.1414 Sung NS, Crowley WF, Genel M, et al. Central challenges facing the national clinical research enterprise. JAMA. 2003; 289(10):1278-87.
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2003 |
Narrative Review |
Unites States |
Research and Innovation |
The core challenges facing clinical research can be listed in public participation, information systems, workforce training and funding. |
Davis D1515 Davis D, Evans M, Jadad A, et al. The case for knowledge translation: shortening the journey from evidence to effect. BMJ. 2003; 327(7405):33-5.
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2003 |
Narrative Review |
Canada |
General practitioner |
Further research is needed to discuss and test knowledge translation models, determining which domains and clinical contexts are most appropriate and which interventions produce results from medical care. |
Hörig et al.1616 Hörig H, Marincola E, Marincola FM. Obstacles and opportunities in translational research. Nat Med. 2005; 11(7):705-8.
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2005 |
Opinion Article |
Unites States |
General practitioner |
A new model of healthcare practices is paramount and should seek better communication between basic scientists, general practitioners, health professionals and patients. |
Graham et al.1717 Graham ID, Logan J, Harrison MB, et al. Lost in knowledge translation: Time for a map? J Contin Educ Health Prof. 2006; 26(1):13-24.
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2006 |
Narrative Review |
Canada |
Health education |
The implications of translating knowledge for continuing education in health professions include the need to be based on the best available knowledge, the use of proven and effective educational strategies, and the value of learning about planning theories for change in practice. |
Khoury et al.1818 Khoury MJ, Gwinn M, Yoon PW, et al. The continuum of translation research in genomic medicine: how can we accelerate the appropriate integration of human genome discoveries into health care and disease prevention? Genet Med. 2007; (9):665-74.
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2007 |
Narrative Review |
Unites States |
Genomics |
The complete continuum of translational research needs adequate support in genetics, since a maximum of 3% of research published in this field so far focuses on T2 onwards and evidence-based guidelines and research on T3 and T4 are very rare. |
Westfall et al.1919 Westfall JM, Mold J, Fagnan L. Practice-Based Research - "Blue Highways" on the NIH Roadmap. JAMA. 2007; 297(4):403.
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2007 |
Opinion Article |
Unites States |
General practitioner |
Practice-based research is a crucial scientific step for the major medical advances of the next 25 years. |
Woolf SH22 Woolf SH. The Meaning of Translational Research and Why It Matters. JAMA. 2008; 299:211-3.
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2008 |
Opinion Article |
Unites States |
Research and Innovation |
The appropriate investment in T2 research is vital to recover the investments in T1 research, because bringing a medicine to the market without knowing how to bring it to the patients impairs its major objective. |
Contopoulos-Ioannidis et al.2020 Contopoulos-Ioannidis DG, Alexiou GA, Gouvias TC, et al. Life cycle of translational research. Science. 2008; 321:1298-9.
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2008 |
Systematic review |
Greece |
Medicines |
Successful translation takes a lot of effort and time, even under the best of circumstances. However, making unrealistic promises for breakthroughs and quick cures can undermine the credibility of science in the public eye. |
Dougherty et al.2121 Dougherty D, Conway PH. The "3T's" Road Map to Transform US Health Care. JAMA. 2008; 299(19):2319.
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2008 |
Opinion Article |
Unites States |
Collective Health |
Starting a national discussion involving all participants in the translational research phases is a first step in improving health outcomes and transforming the health system of the USA. |
Rubio et al.88 Rubio DM, Schoenbaum EE, Lee LS, et al. Defining translational research: implications for training. Acad Med. 2010; 85(3):470-5.
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2010 |
Narrative Review |
Unites States |
Health education |
Translational research moves in a bidirectional manner from one type of research to another, from basic research to population-based research and vice versa, involving collaboration between scientists from various disciplines. |
McClain DA2222 McClain DA. Bridging the gap between basic and clinical investigation. Trends Biochem Sci. 2010; 35:187-8.
|
2010 |
Opinion Article |
Unites States |
General practitioner |
As mechanisms for promoting translational research, it stands out, among others, the training of individuals across the whole spectrum of translations, the simplification of the process of knowledge translation, the application of advances in computer science, image generation and data analysis to translational research and career development of translational researchers. |
Morris et al.1010 Morris ZS, Wooding S, Grant J. The answer is 17 years, what is the question: understanding time lags in translational research. J R Soc Med. 2011; 104:510-20.
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2011 |
Narrative Review |
England |
General practitioner |
Although little is yet known about the timing of delays and how they should be managed, translating scientific findings to benefit patients faster is a political priority of many health research systems. |
Trochim et al.1111 Trochim W, Kane C, Graham MJ, et al. Evaluating translational research: A process marker model. Clin Transl Sci. 2011; 4:153-62.
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2011 |
Narrative Review |
Unites States |
General practitioner |
Although there is still no consensus on translational phase models, there is little doubt that evaluation will be essential to manage translational research effectively. |
Cabieses et al.2323 Cabieses B, Espinoza MA. La investigación traslacional y su aporte para la toma de decisiones en políticas de salud. Rev peru med exp salud publica. 2011; 28(2):288-297.
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2011 |
Systematic review |
Chile |
Collective Health |
The incorporation of a translational perspective can become a priority for any country seeking to define what should be investigated, who should finance and how much resources should be invested in each stage of the research, in favor of the health of the population. |
Guimarães R44 Guimarães R. Pesquisa Translacional: uma interpretação. Ciênc. Saúde Colet. 2013; 18:1731-44.
|
2013 |
Opinion Article |
Brazil |
Research and Innovation |
The universal health system as a fundamental part of the ecosystem of the demands of innovation by society. |
Fishburn CS55 Fishburn CS. Translational research: The changing landscape of drug discovery. Drug Discov Today. 2013; 18(9-10):487-94.
|
2013 |
Opinion Article |
Unites States |
Medicines |
Translational research represents a dominant strategy in the field of medicine discovery and will be paramount in defining the relationships between its actors in the coming decades. |
Montoya HAC2424 Montoya HAC. Reflexiones sobre la integración de las ciencias básicas biomédicas con la práctica clínica en programas de pregrado. Rev colomb rehabil. 2013; 12:22-30.
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2013 |
Narrative Review |
Colombia |
Health education |
The integration of basic sciences with clinical areas will provide an educational context of greater applicability to future professionals. |
Silva et al.33 Silva AB, Morel CM, Moraes IHS. Proposta conceitual de telessaúde no modelo da pesquisa translacional Proposal for a telehealth concept in the translational research model. Rev Saude Publica. 2014; 48:347-56.
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2014 |
Narrative Review |
Brazil |
Telehealth |
Telehealth is close to translational research by allowing people to connect science and benefit those in health services. |
Hanney et al.11 Hanney SR, Castle-Clarke S, Grant J, et al. How long does biomedical research take? Studying the time taken between biomedical and health research and its translation into products, policy, and practice. Heal Res Policy Syst. 2015; 13:1-18.
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2015 |
Narrative Review |
England |
General practitioner |
It is necessary to distinguish between time elapsed and undesirable delays, as certain periods of time in the translation of research are necessary to ensure the safety, efficacy and cost-benefit of treatments. |
Cohrs et al.99 Cohrs RJ, Martin T, Ghahramani P, et al. Translational medicine definition by the European society for translational medicine. New Horizons Transl Med. 2015; (2):86-8.
|
2015 |
Consensus |
Europe |
General practitioner |
Translational Medicine is defined as "an interdisciplinary branch of the biomedical field, supported by three main pillars: bench, bedside and community". Its objective is to "combine disciplines, resources, knowledge and techniques within these pillars to promote improvements in prevention, diagnosis and therapies". |
NIH2525 National Center for Advancing Translational Sciences. Translational Science Spectrum [internet]. 2015 [acesso em 2019 mar 24]. Disponível em: https://ncats.nih.gov/files/translation-factsheet.pdf. https://ncats.nih.gov/files/translation-...
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2015 |
Fact Sheet |
Unites States |
General practitioner |
The spectrum of translational science is not linear or unidirectional and each stage is based on and informs the others. |
Vivas et al.2626 Vivas LM, Lippi MC, Silva GV, et al. Pesquisa Translacional como abordagem para acelerar a inovação tecnológica em saúde. Espac. 2017; 38(14):25.
|
2016 |
Systematic review |
Brazil |
Research and Innovation |
The translational approach presents the interaction between the translation phases in a dynamic and non-linear way, with activities occurring in parallel and requiring constant feedback. |
Luz PL2727 Luz PL. Medicina translacional - nova fronteira. Rev Soc Cardiol Estado São Paulo. 2018; 28(1):14-19.
|
2018 |
Narrative Review |
Brazil |
General practitioner |
Among other points, it is essential to change culture within universities seeking the integration of basic and clinical research and multidisciplinarity. |