Abstract

TESHIMA, Claudia Akemi Shibuya; WATANABE, Mirian; FONSECA, Cassiane Dezoti da  and  VATTIMO, Maria de Fátima Fernandes. Simvastatin and acute ischemic renal injury in rats. Acta paul. enferm. [online]. 2012, vol.25, n.1, pp. 86-89. ISSN 0103-2100.  http://dx.doi.org/10.1590/S0103-21002012000100015.

OBJECTIVES: The study aimed to verify the protective renal action of simvastatin in an animal model of ischemia / reperfusion for 30 minutes. METHODS: Ischemia was obtained by clamping bilateral renal pedicles for 30 minutes, followed by reperfusion. Male Wistar rats were used, weighing between 250-300g, distributed into the following groups: SHAM (control, without clamping renal), Ischemia (renal ischemia for 30 minutes), Ischemia + Statin (simvastatin 0.5 mg/kg, orally for three days). Renal function (creatinine clearance, Jaffé method), urinary osmolality, and urinary peroxides were evaluated. RESULTS: The results showed that the statin improved renal function, and reduced urinary osmolality along with excretion of PU. CONCLUSION: In summary, the study confirmed the protective renal effects of statins, with an antioxidant action that protects the kidney.

Keywords : Acute kidney injury; Ischemia; Simvastatin [adverse effects]; Rats.