Resumo

SRIVASTAVA, R.M  e  SEABRA, G.M. Preparation and reactions of 3-[3-(aryl)-1,2,4-oxadiazol-5-yl]: propionic acids. J. Braz. Chem. Soc. [online]. 1997, vol.8, n.4, pp. 397-405. ISSN 0103-5053.  http://dx.doi.org/10.1590/S0103-50531997000400013.

The synthesis of title compounds 3a-g, from arylamidoximes 1a-g and succinic anhydride in high yields is described. 1,2,4-Oxadiazoles 3a-f were also obtained by carrying out the reaction in a domestic microwave oven. Preliminary pharmacological evaluations demonstrated that 3b-e possess analgesic properties. Ab initio molecular orbital calculations of the type STO-3G have been performed for compounds 3a, 4a, 5a and 6a.

Palavras-chave : arylamidoximes; bis-1,2,4-oxadiazoles; diaryl-1,2,4-oxadiazoles; ab-initio sto-3g calculations.