Journal of the Brazilian Chemical Society
versión impresa ISSN 0103-5053
FIGUEROA-VILLAR, José D.; CLEMENTE, Fábio C. y SILVA, Ana C. C. da. Synthesis and spectroscopic characterization of 5-diaminomethylidene barbiturates. J. Braz. Chem. Soc. [online]. 2001, vol.12, n.2, pp. 247-254. ISSN 0103-5053. http://dx.doi.org/10.1590/S0103-50532001000200020.
The reaction of amines with dithiocyclohexylidenes is a general reaction for the synthesis of diaminomethylidene barbiturates. When diamines of the type H2N-(CH2)n-NH 2 are used as nucleophiles bicyclic compounds are the major reaction products, with yields increasing as n decreases, n = 2, 3, 4. When n = 6, macrocyclic compounds, novel 18 and 27 member rings, are obtained in very good yields. The 1H and 13C NMR assignment for all products is discussed.
Palabras llave : macrocycles; diaminomethylidene barbiturates; dithiocyclohexylidenes; dithiolane.