Abstract

SIANI, Antonio C. et al. Chemical composition and anti-inflammatory activity of the hydrodistillate from Mariscus pedunculatus. J. Braz. Chem. Soc. [online]. 2001, vol.12, n.3, pp. 354-359. ISSN 0103-5053.  http://dx.doi.org/10.1590/S0103-50532001000300006.

A mixture of the benzofuran remirol and the benzopyran isoevodionol (5.7:1) was extracted by hydrodistillation from rhizomes of Mariscus pedunculatus. They were purified by successive thin layer chromatography. Their structure elucidation were confirmed by 2D-NMR experiments. The structure of remirol was also confirmed by its hydrogenation product. Crude distillate and the pure compounds were screened for anti-inflammatory activity by the use of the mouse pleurisy model induced by lipopolysaccharide (LPS, 12.5 ng/cavity). Both the mixture and remirol showed a dose-dependent (100 and 200 mg kg^-1 p. o.) capacity to inhibit neutrophil and eosinophil accumulation in the mouse pleural cavity. In contrast, no anti-inflammatory effect was observed for iso-evodionol.

Keywords : Mariscus pedunculatus; benzofuran derivative; remirol; iso-evodionol; anti-inflammatory activity.