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Journal of the Brazilian Chemical Society

versión impresa ISSN 0103-5053

Resumen

BRAGA, Vanildo Martins L.; MELO, Sebastião J. de; SRIVASTAVA, Rajendra M.  y  FALCAO, Emerson Peter da S.. Synthesis of new 1,2,4-oxadiazoles carrying (1'S,2'S)-t-butyloxycarbonyl-1-amino-2- methyl-1-butyl and (1'S)-t-butyloxycarbonyl-1'-amino-1'-ethyl groups at C-5. J. Braz. Chem. Soc. [online]. 2004, vol.15, n.4, pp. 603-607. ISSN 0103-5053.  http://dx.doi.org/10.1590/S0103-50532004000400025.

A facile and efficient synthesis of 3-aryl-5-[(1S)-t-butyloxycarbonyl-1-amino-(2 S)-methyl-1-butyl)]-1,2,4-oxadiazoles 4a-f and 3-phenyl-5-[(1S)-t-butyloxycarbonyl-1-amino-1-ethyl]-1,2,4 -oxadiazole 6 starting from arylamidoximes, N-t-Boc-L-isoleucine and N-t- Boc-L-alanine is decribed. The structures of the intermediates and final compounds have been deduced from spectroscopic data.

Palabras llave : chiral drugs; 1,2,4-oxadiazoles; arylamidoximes; isoleucine; alanine; antiinflammatory; antipyretic.

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