Journal of the Brazilian Chemical Society
versión impresa ISSN 0103-5053
MADUREIRA, Ana M. et al. Isoprenoid compounds from Euphorbia portlandica. X-ray structure of lupeportlandol, a new lupane triterpene. J. Braz. Chem. Soc. [online]. 2004, vol.15, n.5, pp. 742-747. ISSN 0103-5053. http://dx.doi.org/10.1590/S0103-50532004000500021.
Phytochemical survey of the Me2CO extracts of the whole dried plant Euphorbia portlandica led to the isolation of a new pentacyclic triterpene alcohol, with the lupane skeleton, named lupeportlandol. Its structure was established as 3a-hydroxy-19aH-lup-20(29)-ene. The known pentacyclic triterpene glutinol and the steroid b-sitostenone were also isolated. The characterization of the new compound and its acetylated derivative was based on spectroscopic methods and an X-ray diffraction analysis. Lupeportlandol acetate was inactive in cytotoxicity assays in vitro against three human tumor cell lines: MCF-7 (breast cancer), NCI-H460 (non-small cell lung cancer) and SF-268 (CNS cancer).
Palabras llave : Euphorbia portlandica; triterpenes; steroids; lupane; X-ray diffraction.