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Short synthesis of a new cyclopentene-1,3-dione derivative isolated from Piper carniconnectivum

The total synthesis of cyclopentene-1,3-dione (1), a new natural cyclopentenedione derivative isolated from the roots of Piper carniconnectivum, is described in 8 steps and 11% overall yield from 2-acetylfuran, giving a 57:43 mixture of the two possible geometric isomers 1a and1b.

aldol reaction; allylic alcohol oxidation; cyclopentenedione derivative; Piper carniconnectivum


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