Journal of the Brazilian Chemical Society
On-line version ISSN 1678-4790
SAGRERA, Gabriel J. and SEOANE, Gustavo A.. Microwave accelerated solvent-free synthesis of flavanones. J. Braz. Chem. Soc. [online]. 2005, vol.16, n.4, pp. 851-856. ISSN 1678-4790. http://dx.doi.org/10.1590/S0103-50532005000500026.
Microwave irradiation of chalcones under solvent-free conditions resulted in a "green-chemistry" procedure for the preparation of flavanones in very good yields. Using an unmodified household microwave oven, different mineral supports and catalysts were tested. By irradiation of chalcones with 30% TFA over silica gel, eleven known flavanones and five new compounds were prepared in high yields.
Keywords : cyclization; flavanones; Michael addition; microwave; silica gel.