Journal of the Brazilian Chemical Society
On-line version ISSN 1678-4790
PERIN, Gelson et al. Clean and atom-economic synthesis of a-phenylselenoacrylonitriles and a-phenylseleno- a,b-unsaturated esters by knoevenagel reaction under solvent-free conditions. J. Braz. Chem. Soc. [online]. 2005, vol.16, n.4, pp. 857-862. ISSN 1678-4790. http://dx.doi.org/10.1590/S0103-50532005000500027.
A simple, clean and efficient method has been developed for the synthesis of a-phenylselenoacrylonitriles and a-phenylseleno-a,b-unsaturated esters by a one-pot reaction of aldehydes with phenylselenoacetonitrile or ethyl(phenylseleno)acetate respectively, in the presence of a solid supported catalyst (KF/Al2O3), without any solvent.
Keywords : solvent-free reaction; Knoevenagel condensation; phenylselenoacrylonitriles.