Abstract

BONACORSO, Helio G. et al. Regiospecific synthesis of new non-condensed heteropolycyclic systems from b-heteroaryl-b-methoxyvinyl trihalomethyl ketones. J. Braz. Chem. Soc. [online]. 2005, vol.16, n.4, pp. 868-873. ISSN 0103-5053.  http://dx.doi.org/10.1590/S0103-50532005000500029.

A novel series of twelve heteroaroyl-2-pyrazolines trihalomethyl and substituted heteroaryl, as non-condensed heteropolycyclic systems, have been synthesized in one-step in 50-78% yield from the regiospecific cyclocondensation reaction of 1,1,1-trifluoro(chloro)-4-methoxy-4-(2-furyl)- and 4-(2-thienyl)-3-buten-2-ones (b-alkoxyvinyl trihalometil ketones) with furoic hydrazide, 2-thiophenecarboxylic hydrazide and isonicotinic acid hydrazide (heteroaroylhydrazines) under mild conditions in methanol as solvent.

Keywords : 2-pyrazolines; pyrazoles; 4-alkoxy-1,1,1-trihalo-alk-3-en-2-ones; hydrazides; heteroaroylhydrazines; hydrazines.