Abstract

ZEYNIZADEH, Behzad  and  BEHYAR, Tarifeh. Fast and efficient method for reduction of carbonyl compounds with NaBH₄ /wet SiO₂ under solvent free condition. J. Braz. Chem. Soc. [online]. 2005, vol.16, n.6a, pp. 1200-1209. ISSN 0103-5053.  http://dx.doi.org/10.1590/S0103-50532005000700018.

Reduction of structurally different carbonyl compounds such as aldehydes, ketones, a,b-unsaturated enals and enones, a-diketones and acyloins were accomplished efficiently by sodium borohydride in the presence of wet SiO₂ (30% m/m) under solvent free condition. The reactions were performed at room temperature or 75-80 ºC with high to excellent yields of the corresponding products. The chemoselective reduction of aldehydes over ketones was achieved successfully with this reducing system.

Keywords : reduction; NaBH₄; wet SiO₂; solvent free.