Journal of the Brazilian Chemical Society
On-line version ISSN 1678-4790
ZANATTA, Nilo et al. Synthesis of N-substituted 6-trifluoromethyl-1,3-oxazinanes. J. Braz. Chem. Soc. [online]. 2005, vol.16, n.6a, pp.1255-1261. ISSN 1678-4790. http://dx.doi.org/10.1590/S0103-50532005000700025.
This work reports the synthesis of two new series of N-substituted 6-trifluoromethyl-1,3-oxazinanes and N-substituted 6-trifluoromethyl-1,3-oxazinan-2-ones from the cyclization of 4-ylamino-1,1,1-trifluoro-butan-2-ols with formaldehyde and triphosgene, respectively. The 4-ylamino-1,1,1-trifluoro-butan-2-ols were obtained in good yields from the reduction of the parent 4-ylamino-1,1,1-trifluoro-but-3-en-2-ones with hydrogen and 10% Pd/C.
Keywords : g-amino alcohols; b-enamino ketones; 1,3-oxazinanes; 1,3-oxazinan-2-ones; 1,3-oxazines.