Resumo

IDE, Regina M.; COSTA, Marta  e  IMAMURA, Paulo M.. Synthesis of Ent-16-hydroxycleroda-4(18),13-dien-15,16-olide and Ent-cleroda-4(18),13-dien-15,16-olide from (+)-hardwickiic acid. J. Braz. Chem. Soc. [online]. 2006, vol.17, n.2, pp. 417-420. ISSN 0103-5053.  http://dx.doi.org/10.1590/S0103-50532006000200029.

The absolute configurations of two natural diterpene butenolides were confirmed through the synthesis of ent-16-hydroxycleroda-4(18),13-dien-15,16-olide (2) and ent-cleroda-4(18),13-dien-15,16-olide (3), enantiomers of the natural products, starting from (+)-hardwickiic acid (1).

Palavras-chave : (+)-hardwickiic acid; clerodane; butenolide; absolute configuration.