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Journal of the Brazilian Chemical Society
On-line version ISSN 1678-4790
CERCHIARO, Giselle and FERREIRA, Ana Maria da Costa. Oxindoles and copper complexes with oxindole-derivatives as potential pharmacological agents. J. Braz. Chem. Soc. [online]. 2006, vol.17, n.8, pp. 1473-1485. ISSN 1678-4790. http://dx.doi.org/10.1590/S0103-50532006000800003.
Oxindoles are endogenous compounds found in mammalian body fluids and tissues. Particularly, isatin (1H-indole-2,3-dione) and its derivatives have shown a variety of biological effects, including inhibition of monoamine oxidase, antibacterial, antifungal, antiviral and antiproliferative activities. Recent reports have described these compounds as efficient inhibitors of kinases, a class of proteins involved in many steps of the cellular cycle. Here, some copper(II) complexes with oxindole-derived ligands are discussed as potential antitumoral agents, in comparison to other complexes, based on the proposal of a synergistic effect on adding the metal coordinating and redox properties to the already demonstrated capability of these ligands to influence the angiogenesis and apoptosis processes.
Keywords : copper; oxindole derivatives; metallodrugs; apoptosis; redox regulation.