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vol.17 issue8Synthesis and crystal structures of new complex salts containing both cationic and anionic tellurium(IV) species: the role of secondary bonds in the arrangement of tellurium based tectonsNovel zwitterionic oxorhenium(V) complexes: synthesis, characterization and crystal structure of [ReOX2(Hdhp)(PPh3)] (X = Cl, Br; H2dhp = 2,3-dihydroxypyridine) author indexsubject indexarticles search
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Journal of the Brazilian Chemical Society

Print version ISSN 0103-5053On-line version ISSN 1678-4790


MENDES, Isolda C. et al. N(4)-tolyl-2-benzoylpyridine thiosemicarbazones and their copper(II) complexes with significant antifungal activity: crystal structure of N(4)-para-tolyl-2-benzoylpyridine thiosemicarbazone. J. Braz. Chem. Soc. [online]. 2006, vol.17, n.8, pp.1571-1577. ISSN 0103-5053.

Três complexos inéditos do tipo [Cu(HL)Cl2] foram obtidos com N(4)-orto (H2Bz4oT, HL1), N(4)-meta (H2Bz4mT, HL2) e N(4)-para-toluil-2-benzoilpiridina tiossemicarbazona (H2Bz4pT, HL3), nos quais a tiossemicarbazona coordena-se ao metal por meio do sistema quelante Npy-N-S. H2Bz4pT (HL3) cristaliza-se no grupo espacial P1, a = 9,509(3) Å, b = 9,807(4) Å, c = 11,564(4) Å; a = 100,76(2)°, b = 105,99(2)°, g = 114,59(2)°. Tanto as tiossemicarbazonas quanto seus complexos de cobre(II) apresentaram atividade antifúngica pronunciada contra Candida albicans, com valores baixos de concentração inibitória mínima (CIM), entre 8 e 0,3 µg mL-1 (23 a 0,7 µmol L-1) para as tiossemicarbazonas e entre 1 e 0,1 µg mL-1 (2 a 0,3 µmol L-1) para os complexos. Nossos resultados sugerem que a coordenação ao cobre constitui estratégia interessante de redução da dose necessária à atividade.

Keywords : thiosemicarbazones; copper(II) complexes; antifungal activity; Candida albicans.

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