Abstract

DI NEZIO, María S. et al. A home-made hybrid system for the simultaneous determination of ergotamine, dipyrone and caffeine in pharmaceutical preparations. J. Braz. Chem. Soc. [online]. 2007, vol.18, n.7, pp. 1439-1442. ISSN 0103-5053.  http://dx.doi.org/10.1590/S0103-50532007000700020.

A novel home-made hybrid detection system was designed for simultaneous determination of caffeine (CAF), dipyrone (DIP) and ergotamine (ERG) in pharmaceutical preparations. Thus, ERG was determined by a fluorimetric signal and PLS-1 method for resolving DIP and CAF UV-Vis spectral data was used. The calibration curve for ERG was linear over the range 2.5-10 mg L^-1. The calibration set consisted of 18 mixtures with 0.5 to 4 mg L^-1 for CAF, 5 to 20 mg L^-1 for DIP and 2.5 and 10 mg L^-1 for ERG. Sample preparation prior to analysis was not required. A recovery study with the real samples was carried out and the obtained results were highly satisfactory.

Keywords : hybrid system; ergotamine; dipyrone; caffeine; simultaneous determination, PLS-1.