SciELO - Scientific Electronic Library Online

 
vol.19 issue6A gas chromatographic method for the determination of the fungicide chlorothalonil in tomatoes and cucumbers and its application to dissipation studies in experimental greenhousesStudy of the electrochemical reduction of amoebicide teclozan and its amperometric determination in pharmaceutical formulations author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Journal of the Brazilian Chemical Society

Print version ISSN 0103-5053On-line version ISSN 1678-4790

Abstract

PILAU, Eduardo J.; SILVA, Raquel G. C.; JARDIM, Isabel C. F. S.  and  AUGUSTO, Fabio. Molecularly imprinted sol-gel silica for solid phase extraction of phenobarbital. J. Braz. Chem. Soc. [online]. 2008, vol.19, n.6, pp.1136-1143. ISSN 0103-5053.  http://dx.doi.org/10.1590/S0103-50532008000600013.

A molecularly imprinted organically modified silica was prepared through a simple sol-gel procedure, and evaluated as specific sorbent for solid-phase extraction (SPE) of phenobarbital from aqueous and forensic samples. The analytical properties of the molecularly imprinted silica (MIS, non-imprinted sílica) were initially evaluated and the MIS was found to be specific towards the target species: the imprinting factor IF, measured as the ratio between phenobarbital peak areas in the MIS and NIS chromatograms, was estimated as 58. This value is considerably higher than those usually found for conventional methacrylate-based molecularly imprinted sorbents and suggests that non-specific analyte/sorbent interactions are insignificant in the MIS. This material is applied to the isolation of phenobarbital from aqueous samples and plasma; detection limit of 10 and 62 µg mL-1 was achieved for the former samples, respectively.

Keywords : molecularly imprinted silica; sol-gel; ormosils; phenobarbital; SPE.

        · abstract in Portuguese     · text in English     · English ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License