SciELO - Scientific Electronic Library Online

vol.20 issue5Synthesis, characterization and kinetics of catalytically active molecularly imprinted polymers for the selective recognition of 4-aminophenolFlame atomic absorption spectrometric determination of trace amounts of cobalt after cloud point extraction as 2-[(2-Mercaptophenylimino)methyl]phenol complex author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Journal of the Brazilian Chemical Society

Print version ISSN 0103-5053On-line version ISSN 1678-4790


SUN, Xian-Yu et al. Design, synthesis and anticonvulsant activity evaluation of 7-substituted-4H-[1,2,4]triazino[3,4-a]phthalazin-4-one derivatives. J. Braz. Chem. Soc. [online]. 2009, vol.20, n.5, pp.826-831. ISSN 0103-5053.

In this study, a novel series of 7-substituted-4H-[1,2,4]triazino[3,4-a]phthalazin-4-one derivatives was synthesized as potential anticonvulsant agents. Their anticonvulsant activities were evaluated by the maximal electroshock (MES) test, and their neurotoxicities were evaluated by the rotarod neurotoxicity test. The pharmacological results showed that 7-hexyloxy-4H-[1,2,4]triazino[3,4-a]phthalazin-4-one 4e was the most potent with median effective dose (ED50) value of 6.6 mg kg-1, median toxicity dose (TD50) of 39.4 mg kg-1, providing a protective index (PI=TD50 /ED50) value of 6.0.

Keywords : triazino; phthalazine; anticonvulsant; neurotoxicity.

        · abstract in Portuguese     · text in English     · English ( pdf epdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License