Journal of the Brazilian Chemical Society
On-line version ISSN 1678-4790
GANJALI, Mohammad Reza et al. A new homatropine potentiometric membrane sensor as a useful device for homatropine hydrobromide analysis in pharmaceutical formulation and urine: a computational study. J. Braz. Chem. Soc. [online]. 2009, vol.20, n.5, pp.926-934. ISSN 1678-4790. http://dx.doi.org/10.1590/S0103-50532009000500018.
Homatropine (Equipin, Isopto Homatropine) is an anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It is available as the hydrobromide or methylbromide salt. In this study, a potentiometric liquid membrane sensor for simple and fast determination of homatropine hydrobromide in pharmaceutical formulation and urine was constructed. For the membrane preparation, homatropine-tetraphenylborate complexes were employed as electroactive materials in the membrane. The proposed sensor presents wide linear range (10-5-10-1 mol L-1), low detection limit (8×10-6 mol L-1), and fast response time (ca. 10 s). Validation of the method shows suitability of the sensors for applicability in the quality control analysis of homatropine hydrobromide in pharmaceutical formulation and urine.
Keywords : potentiometric sensor; PVC membrane; homatropine hydrobromide; chemometrics; density functional based tight binding (DFTB).