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Journal of the Brazilian Chemical Society

Print version ISSN 0103-5053

Abstract

TAPIA, Ricardo A.; CANTUARIAS, Lorena; CUELLAR, Mauricio  and  VILLENA, Joan. Microwave-assisted reaction of 2,3-dichloronaphthoquinone with aminopyridines. J. Braz. Chem. Soc. [online]. 2009, vol.20, n.5, pp. 999-1002. ISSN 0103-5053.  http://dx.doi.org/10.1590/S0103-50532009000500027.

The synthesis of pyridylaminonaphthoquinones by microwave-assisted reaction of 2,3-dichloro-1,4-naphthoquinone with aminopyridines is described. The use of microwave irradiation diminished the reaction times and improved the yields substantially in all these reactions. The compounds were tested for their cytotoxic activities against MCF-7 breast cancer cell line.

Keywords : 2,3-dichloronaphthoquinone; microwave irradiation; aminopyridines; cytotoxic activity.

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