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Journal of the Brazilian Chemical Society

Print version ISSN 0103-5053

Abstract

BUSKUHL, Humberto et al. A new polyacetylene from Vernonia scorpioides (Lam.) Pers. (Asteraceae) and its in vitro antitumoral activity. J. Braz. Chem. Soc. [online]. 2009, vol.20, n.7, pp. 1327-1333. ISSN 0103-5053.  http://dx.doi.org/10.1590/S0103-50532009000700018.

The dichloromethane fraction obtained from hydroalcoholic crude extract of leaves and flowers of Vernonia scorpioides (Asteraceae) was investigated, resulting in the isolation and structure elucidation of a new polyacetylene namely 5-octa-2,4,6-triynyl-furan-2(5H)-one. The structure of the isolated compound was determined based on IR, NMR (1D and 2D) and MS spectrometric data. The antitumor potential, including cytotoxicity to tumor cells and genotoxicity, was investigated. The results suggest that apoptotic cell death may have occurred, at least in part, via a caspase-dependent mechanism.

Keywords : polyacetylene; Vernonia scorpioides; cytotoxicity; genotoxicity; Asteraceae.

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