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Journal of the Brazilian Chemical Society
versión On-line ISSN 1678-4790
BUSKUHL, Humberto et al. A new polyacetylene from Vernonia scorpioides (Lam.) Pers. (Asteraceae) and its in vitro antitumoral activity. J. Braz. Chem. Soc. [online]. 2009, vol.20, n.7, pp. 1327-1333. ISSN 1678-4790. http://dx.doi.org/10.1590/S0103-50532009000700018.
The dichloromethane fraction obtained from hydroalcoholic crude extract of leaves and flowers of Vernonia scorpioides (Asteraceae) was investigated, resulting in the isolation and structure elucidation of a new polyacetylene namely 5-octa-2,4,6-triynyl-furan-2(5H)-one. The structure of the isolated compound was determined based on IR, NMR (1D and 2D) and MS spectrometric data. The antitumor potential, including cytotoxicity to tumor cells and genotoxicity, was investigated. The results suggest that apoptotic cell death may have occurred, at least in part, via a caspase-dependent mechanism.
Palabras clave : polyacetylene; Vernonia scorpioides; cytotoxicity; genotoxicity; Asteraceae.