An easy synthesis of 3,5-disubstituted 1,2,4-oxadiazoles from carboxylic acids and arylamidoximes mediated by ethyl chloroformate

An efficient, clean and easy high-yielding synthesis of 3,5-disubstituted 1,2,4-oxadiazoles starting from mixed anhydrides (generated from carboxylic acids and ethyl chloroformate) and arylamidoximes is described.

carboxylic acids; arylamidoximes; 1,2,4-oxadiazoles; 1H and 13C NMR spectra