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Journal of the Brazilian Chemical Society
Print version ISSN 0103-5053
GAO, Wentao; ZHANG, Chaohua and LI, Yang. A novel one-pot three-step synthesis of 2-(1-Benzofuran-2-yl)quinoline-3-carboxylic acid derivatives. J. Braz. Chem. Soc. [online]. 2010, vol.21, n.5, pp.806-812. ISSN 0103-5053. http://dx.doi.org/10.1590/S0103-50532010000500007.
A facile and efficient one-pot three-step procedure for the preparation of 2-(1-benzofuran-2-yl)quinoline-3-carboxylic acid derivatives is described, featuring three different synthetic transformations, namely Williamson ether synthesis, hydrolysis of an ester group at the quinoline ring C-3 position, and intramolecular electrophilic cyclization reaction between the aldehyde group of salicylaldehyde and the methylene at the quinoline ring C-2 position.
Keywords : one-pot; three-step; benzofuran; quinoline.