Journal of the Brazilian Chemical Society
versión impresa ISSN 0103-5053
ALI, Tarik El-Sayed y IBRAHIM, Magdy Ahmed. Synthesis and antimicrobial activity of chromone-linked 2-pyridone fused with 1,2,4-triazoles, 1,2,4-triazines and 1,2,4-triazepines ring systems. J. Braz. Chem. Soc. [online]. 2010, vol.21, n.6, pp. 1007-1016. ISSN 0103-5053. http://dx.doi.org/10.1590/S0103-50532010000600010.
Three series of novel fused nitrogen heterocyclic systems such as 1,2,4-triazolo[1,5-α ] pyridines (5-7 and 9), pyrido[1,2-b][1,2,4]triazines (10, 11, 13 and 15), and pyrido[1,2-b][1,2,4]triazepines (17, 18, 20 and 22) linked with a chromone moiety were synthesized from the key intermediate 1,6-diamino-(6-chloro-4-oxo-4H-chromen-3-yl)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile (4) with some electrophilic reagents. The structures of the novel compounds were established by elemental analyses and spectral data. All the products were also screened invitro for their antimicrobial activity. Compounds 7, 9 and 15 showed the highest activities when compared with the reference drugs.
Palabras clave : chromone; o-diamine; triazolopyridone; pyridotriazine; pyridotriazepine; antimicrobial activity.