Abstract

GRESSLER, Vanessa et al. Antioxidant and antimicrobial properties of 2-(4,5-dihydro-1H-pyrazol-1-yl)-pyrimidine and 1-carboxamidino-1H-pyrazole derivatives. J. Braz. Chem. Soc. [online]. 2010, vol.21, n.8, pp. 1477-1483. ISSN 0103-5053.  http://dx.doi.org/10.1590/S0103-50532010000800010.

Five previously synthesized 4-trifluoromethyl-2-(5-aryl-3-styryl-1H-pyrazol-1yl)-pyrimidines and six 5-aryl-3-styryl-1-carboxamidino-1H-pyrazole derivatives were screened for their antioxidant proprieties. The antioxidant activities were evaluated by using the DPPH and the HRP/luminol/H₂O₂ chemiluminescence assay systems and for their antimicrobial activity (MIC). The results were good for those series in some concentration in comparison with the standards.

Keywords : heterocycles; 4,5-dihydropyrazoles; antioxidant activity; antimicrobial activity.