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Journal of the Brazilian Chemical Society

versión impresa ISSN 0103-5053


SILVA, Bárbara V; ESTEVES, Pierre M  y  PINTO, Angelo C. Chlorination of isatins with trichloroisocyanuric acid. J. Braz. Chem. Soc. [online]. 2011, vol.22, n.2, pp.257-263. ISSN 0103-5053.

Isatin and its derivatives have been extensively reported in the literature as having range of potential pharmacological compounds. The Sandmeyer method is the most widely used for isatin synthesis and furnishes different substituted isatins, usually with high yields. Although efficient, the Sandmeyer route has certain limitations, such as the formation of a mixture of regiosiomers and low yields depending on the type and position of the substituent. Thus, overcome these limitations, it is preferable that some derivative isatins be obtained by alternative methods. This article has investigated the chlorination of isatin derivatives using trichloroisocyanuric acid [1,3,5-trichloro 1,3,5-triazine-2,4,6-(1H,3H,5H)-trione or TCCA] at different reaction conditions.

Palabras clave : isatin; trichloroisocyanuric acid; chlorination.

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