SciELO - Scientific Electronic Library Online

vol.22 número2Multivariate spectroscopic determination of the lamivudine-zidovudine associationSynthesis and antileishmanial activity of new 1-aryl-1H-pyrazole-4-carboximidamides derivatives índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados




Links relacionados


Journal of the Brazilian Chemical Society

versión impresa ISSN 0103-5053


BABAEI, Ali; AFRASIABI, Mohammad; MIRZAKHANI, Somaieh  y  TAHERI, Ali Reza. A sensitive determination of acetaminophen in pharmaceutical preparations and biological samples using multi-walled carbon nanotube modified glassy carbon electrode. J. Braz. Chem. Soc. [online]. 2011, vol.22, n.2, pp.344-351. ISSN 0103-5053.

A chemically modified electrode is constructed based on multi-walled carbon nanotube modified glassy carbon electrode (MWCNTs/GCE). It was demonstrated that this sensor could be easily used for determination of acetaminophen (ACT) in aqueous buffered media. The measurements were carried out by application of differential pulse voltammetry (DPV), cyclic voltammetry (CV) and chronoamperometry (CA) methods. Application of DPV method showed two linear dynamic ranges. The first linear dynamic range was from 0.1 to 22 µmol L-1, with a calibration equation of Ip(µA) = 1.2782c (µmol L-1) + 0.2431 (R2 = 0.9984) and the second linear dynamic range was between 26 to 340 µmol L-1 with a calibration equation of Ip(µA) = 0.7793c (µmol L-1) + 11.615 (R2 = 0.9986). A detection limit of 0.029 µmol L-1 (S/N = 3) was obtained. The modified electrode showed electrochemical responses with high sensitivity, excellent selectivity and stability for ACT determination at optimal conditions, which makes it a suitable sensor for submicromolar detection of ACT in solutions. The analytical performance of this sensor has been evaluated for detection of ACT in human serum, human urine and a pharmaceutical preparation with satisfactory results.

Palabras clave : acetaminophen; carbon nanotube; modified glassy carbon; electrochemical sensor.

        · resumen en Portugués     · texto en Inglés     · Inglés ( pdf epdf )


Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons