Journal of the Brazilian Chemical Society
versión impresa ISSN 0103-5053
SANTOS, Maurício S. dos et al. Synthesis and antileishmanial activity of new 1-aryl-1H-pyrazole-4-carboximidamides derivatives. J. Braz. Chem. Soc. [online]. 2011, vol.22, n.2, pp. 352-358. ISSN 0103-5053. http://dx.doi.org/10.1590/S0103-50532011000200022.
Chemotherapy for leishmaniasis, diseases caused by protozoa of the genus Leishmania, remains inefficient in several treatments. So there is a need to search for new drugs. In this work, we have synthesized 1-aryl-1H-pyrazole-4-carboximidamides derivatives and evaluated antileishmanial activities in vitro, as well as cytotoxic effects. Structure-activity relationship (SAR) studies were carried out with all the compounds of the series. Compound 2 showed an activity profile that can be improved through medicinal chemistry strategies.
Palabras llave : synthesis; 1-aryl-1H-pyrazole-4-carboximidamides; leishmaniasis.