Resumo

YAO, Guangmin et al. Citrinin derivatives from the soil filamentous fungus Penicillium sp. H9318. J. Braz. Chem. Soc. [online]. 2011, vol.22, n.6, pp. 1125-1129. ISSN 0103-5053.  http://dx.doi.org/10.1590/S0103-50532011000600018.

Investigation of a microbial fermentation organic extract of Penicillium sp. H9318 led to the isolation of a new isoquinolinone alkaloid, (5S)-3,4,5,7-tetramethyl-5,8-dihydroxyl-6(5H)-isoquinolinone (1), along with four known citrinin derivatives (2-5). Citrinin (2) exhibited significant inhibitory activity against Streptomyces 85E in the hyphae formation inhibition (HFI) assay, while compounds 1, 3-5 were not active when tested at 20 mg/disk in the HFI assay. Citrinin (2) further demonstrated a weak inhibitory activity against MCF-7 (IC₅₀ 71.93 µmol L^-1), LNCaP (IC₅₀ 77.92 µmol L^-1), LU-1 (147.85 µmol L^-1) and KB (IC₅₀ 65.93 µmol L^-1) cell lines, respectively, in the cytotoxicity assay.

Palavras-chave : Streptomyces 85E; isoquinolinone alkaloid; citrinin; Penicillium sp. H9318; kinase inhibitor.